Potential biomarkers of age-related chronic inflammation

Chronic inflammation is a long-term, low-grade inflammation mostly occurring in elderly individuals and is associated with the development of various chronic diseases. My research focused on observing molecules in human plasma to detect chronic inflammation early, potentially preventing these diseases. I measured concentrations of inflammatory cytokines, soluble protein CD163, and free mitochondrial DNA in 34 plasma samples from young and old individuals using ELISA, PCR, and multiplex bead-based immunoassays. Elevated levels of analytes in older individuals would confirm a connection with ageing and potentially with the development of chronic inflammation. Notably, protein sCD163 emerged as a promising biomarker for age-related chronic inflammation.